CSC Pharmaceuticals International
Gamdevi, Mumbai, Maharashtra
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Injection I

Offering you a complete choice of products which include arixtra, atg 100mg inj, avaxim, bondronat inj, campto and cancidas.

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GSK   
Fondaparinux is used to prevent deep vein thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. This medicine is used for several days after hip fracture surgery, hip or knee replacement surgery, and in some cases following abdominal or stomach surgery, while you are unable to walk. It is during this time that blood clots are most likely to form.  
ANTI THROMBOTIC
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AVENTIS PASTEUR   
"ATGAM Sterile Solution contains lymphocyte immune globulin, anti-thymocyte globulin
[equine]. It is the purified, concentrated, and sterile gamma globulin, primarily
monomeric IgG, from hyperimmune serum of horses immunized with human thymus
lymphocytes. ATGAM is a transparent to slightly opalescent aqueous protein solution. It
may appear colorless to faintly pink or brown and is nearly odorless. It may develop a
slight granular or flaky deposit during storage. (For information about in-line filters, see
Infusion Instructions in the DOSAGE AND ADMINISTRATION SECTION.)
Before release for clinical use, each lot of ATGAM is tested to assure its ability to inhibit
rosette formation between human peripheral lymphocytes and sheep red blood cells in
vitro. In each lot, antibody activity against human red blood cells and platelets is also
measured and determined to be within acceptable limits. Only lots that test negative for
antihuman serum protein antibody, antiglomerular basement membrane antibody and
pyrogens are released.
Each milliliter of ATGAM contains 50 mg of horse gamma globulin stabilized in 0.3
molar to a pH of approximately 6.8. "  
IMMUNOSUPPRESANT / RENAL APLASTIC ANEMIA
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SANOFI PASTEUR   
"AVAXIM is a sterile suspension for injection containing formaldehyde-inactivated
hepatitis A virus (GBM strain) adsorbed onto aluminium hydroxide.
Each 0.5mL dose contains: "   
HEPATITIS A VACCINE
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ROCHE   
"Ibandronate sodium has the full chemical name of [1-hydroxy-3-
(methylpentylamino)propylidene]bis-phosphonic acid, monosodium salt, monohydrate. Its
molecular weight is 359. It is a white to off-white powder and is freely soluble in water.
BONDRONAT is available as a sterile, clear and colourless concentrated injection for
intravenous (IV) infusion containing 6 mg ibandronic acid (as the monosodium salt
monohydrate 6.75 mg). The concentrated injection also contains sodium chloride, acetic acid
- glacial, sodium acetate and water for injections.
BONDRONAT is also available as white to off-white, film-coated tablets containing 50 mg
ibandronic acid (as the monosodium salt monohydrate 56.25 mg). The tablets also contain
lactose, cellulose microcrystalline, povidone, crospovidone, stearic acid and silica colloidal
anhydrous. The tablet film-coating contains hypromellose, titanium dioxide, purified talc and
macrogol 6000. "  
ONCOLOGY
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PFIZER   
"In 1998, the Southern Saltmarsh Mosquito Aedes camptorhynchus (‘Campto’) was accidentally transported from Australia to Hawke’s Bay in New Zealand, from where it dispersed to another 10 localities mainly on the North Island. After an investment of NZ$70 million over 10 years, this saltmarsh carrier of Ross River virus was eradicated in a world-first program which surprised many."
ONCOLOGY
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MSD
"CANCIDAS is a sterile, lyophilized product for intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of Glarea lozoyensis. CANCIDAS is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall.

CANCIDAS (caspofungin acetate) is 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine] pneumocandin B0 diacetate (salt). CANCIDAS 50 mg also contains: 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. CANCIDAS 70 mg also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is C52H88N10O15•2C2H4O2 and the formula weight is 1213.42. The structural formula is: CANCIDAS® (caspofungin acetate) Structural Formula Illustration"    
ANTIFUNGAL
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GENZYME   
"Cerezyme® (imiglucerase for injection) is an analogue of the human enzyme β-glucocerebrosidase, produced by recombinant DNA technology. β-Glucocerebrosidase (β-D-glucosyl-N-acylsphingosine glucohydrolase, E.C. 3.2.1.45) is a lysosomal glycoprotein enzyme which catalyzes the hydrolysis of the glycolipid glucocerebroside to glucose and ceramide.

Cerezyme® (imiglucerase) is produced by recombinant DNA technology using mammalian cell culture (Chinese hamster ovary). Purified imiglucerase is a monomeric glycoprotein of 497 amino acids, containing 4 N-linked glycosylation sites (Mr = 60,430). Imiglucerase differs from placental glucocerebrosidase by one amino acid at position 495, where histidine is substituted for arginine. The oligosaccharide chains at the glycosylation sites have been modified to terminate in mannose sugars. The modified carbohydrate structures on imiglucerase are somewhat different from those on placental gluco-cerebrosidase. These mannose-terminated oligosaccharide chains of imiglucerase are specifically recognized by endocytic carbohydrate receptors on macrophages, the cells that accumulate lipid in Gaucher disease.

Cerezyme® (imiglucerase) is supplied as a sterile, non-pyrogenic, white to off-white lyophilized product. The quantitative composition of the lyophilized drug is provided in the following table:"  
GAUCHER DISEASE
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GSK   
"CERVARIX [Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant] is a non-infectious recombinant, AS04-adjuvanted vaccine that contains recombinant L1 protein, the major antigenic protein of the capsid, of oncogenic HPV types 16 and 18. The L1 proteins are produced in separate bioreactors using the recombinant Baculovirus expression vector system in a serum-free culture media composed of chemically-defined lipids, vitamins, amino acids, and mineral salts. Following replication of the L1 encoding recombinant Baculovirus in Trichoplusia ni insect cells, the L1 protein accumulates in the cytoplasm of the cells. The L1 proteins are released by cell disruption and purified by a series of chromatographic and filtration methods. Assembly of the L1 proteins into virus-like particles (VLPs) occurs at the end of the purification process. The purified, non-infectious VLPs are then adsorbed on to aluminum (as hydroxide salt). The adjuvant system, AS04, is composed of 3-0-desacyl-4'-monophosphoryl lipid A (MPL) adsorbed on to aluminum (as hydroxide salt).

CERVARIX is prepared by combining the adsorbed VLPs of each HPV type together with the AS04 adjuvant system in sodium chloride, sodium dihydrogen phosphate dihydrate, and Water for Injection.

CERVARIX is a sterile suspension for intramuscular injection. Each 0.5-mL dose is formulated to contain 20 mcg of HPV type 16 L1 protein, 20 mcg of HPV type 18 L1 protein, 50 mcg of the 3-0-desacyl-4'-monophosphoryl lipid A (MPL), and 0.5 mg of aluminum hydroxide. Each dose also contains 4.4 mg of sodium chloride and 0.624 mg of sodium dihydrogen phosphate dihydrate. Each dose may also contain residual amounts of insect cell and viral protein ( < 40 ng) and bacterial cell protein ( < 150 ng) from the manufacturing process. CERVARIX does not contain a preservative.

The tip caps may contain natural rubber latex; the plungers are not made with natural rubber latex."  
CERVICAL CANCER VACCINE
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FERRING   
"CHORAGON, Powder and solvent for solution for injection, 1500 IU and 5000 IU
Active ingredient: human chorionic gonadotrophin INDICATION CHORAGON 1500 IU
Paediatrics and andrology Establishment of fertility in case of hypogonadotrophic hypogonadism (also in combination with hMG and FSH). Treatment of undescended testicle. CHORAGON 5000 IU Therapy Gynaecology CHORAGON is indicated in the treatment of: Women undergoing superovulation prior to assisted reproductive techniques such as in vitro fertilisation (IVF): CHORAGON is administered to trigger final follicular maturation and luteinisation after stimulation of follicular growth. Anovulatory or oligo-ovulatory women: CHORAGON is administered to trigger
ovulation and luteinisation in anovulatory or oligo-ovulatory patients after stimulation of follicular growth. "
HUMAN CHIRIONIC GONADOTROPHIN
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SANOFI AVENTIS   
"ELOXATIN® (oxaliplatin injection) is an antineoplastic agent with the molecular formula C8H14N2O4Pt and the chemical name of cis-[(1 R,2 R)-1,2-cyclohexanediamine-N,N'] [oxalato(2)-O,O'] platinum. Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a leaving group.

ELOXATIN (oxaliplatin) Structural Formula Illustration

The molecular weight is 397.3. Oxaliplatin is slightly soluble in water at 6 mg/mL, very slightly soluble in methanol, and practically insoluble in ethanol and acetone.

ELOXATIN is supplied in vials containing 50 mg, 100 mg or 200 mg of oxaliplatin as a sterile, preservative-free, aqueous solution at a concentration of 5 mg/ml. Water for Injection, USP is present as an inactive ingredient."   
ONCOLOGY
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BAXTER ONCOLOGY   
"ENDOXAN (cyclophosphamide) New Zealand Data Sheet
27 February 2012 Page 1 of 26
Baxter
ENDOXAN
Cyclophosphamide powder for inj
ection, 500mg, 1.0g or 2.0g
NAME OF DRUG
ENDOXAN is available in 3 strengths: 500m
g, 1.0g or 2.0g of cyclophosphamide per vial.
DESCRIPTION
Cyclophosphamide is chemically 2-Bis (2-chl
oroethyl) aminoperhydro-1, 3, 2-oxazaphosphorine
2-oxide. It exists as the monohydrat
e. The chemical formula is C
7
H
15
Cl
2
N
2
O
2
P.H
2
O and its
molecular weight is 279.1. The CAS number is
6055-19-2 and the chemical structure is as
follows:
The white crystalline monohydrate is soluble
in water (> 4% w/v). Cyclophosphamide
monohydrate liquefies when its wate
r of crystallisation is lost. "    ONCOLOGY
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GSK   
"ENGERIX-B [Hepatitis B Vaccine (Recombinant)] is a sterile suspension of noninfectious hepatitis B virus surface antigen (HBsAg) for intramuscular administration. It contains purified surface antigen of the virus obtained by culturing genetically engineered Saccharomyces cerevisiae cells, which carry the surface antigen gene of the hepatitis B virus. The HBsAg expressed in the cells is purified by several physicochemical steps and formulated as a suspension of the antigen adsorbed on aluminum hydroxide. The procedures used to manufacture ENGERIX-B result in a product that contains no more than 5% yeast protein.

Each 0.5-mL pediatric/adolescent dose contains 10 mcg of HBsAg adsorbed on 0.25 mg aluminum as aluminum hydroxide.

Each 1-mL adult dose contains 20 mcg of HBsAg adsorbed on 0.5 mg aluminum as aluminum hydroxide.

ENGERIX-B contains the following excipients: Sodium chloride (9 mg/mL) and phosphate buffers (disodium phosphate dihydrate, 0.98 mg/mL; sodium dihydrogen phosphate dihydrate, 0.71 mg/mL).

ENGERIX-B is available in vials and prefilled syringes. The tip caps of the prefilled syringes may contain natural rubber latex; the plungers are not made with natural rubber latex. The vial stoppers are not made with natural rubber latex.

ENGERIX-B is formulated without preservatives.."  
HEPATITIS VACCINE
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JOHNSON & JOHNSON     
Eprex is a popular medicine that is also widely known under the name of Epoetin. This medicine is an artificial version of erythropoietin (EPO). EPO is naturally produced by the organism (mostly in the kidneys). EPO is known to stimulate the patient’s bone marrow, thus increasing its blood cells production. If the body fails to produce enough blood cells, the patient may suffer from severe anemia (this medical condition often occurs in the case of patients who are suffering from kidney disorders). Eprex is widely prescribed to treat and to prevent severe anemia (this medical disorder might be triggered by a variety of medical conditions such as cancer, AIDS, surgery, etc).    ONCOLOGY RELATED ANEMIA
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IPSEN LTD.   
"ERWINAZE (asparaginase Erwinia chrysanthemi) contains an asparagine specific enzyme derived from Erwinia chrysanthemi. L-asparaginase is a tetrameric enzyme consisting of four identical subunits, each having a molecular weight of about 35 kDa. The activity of ERWINAZE is expressed in terms of International Units.

ERWINAZE is supplied as a sterile, lyophilized, white powder in vials. Each vial contains 10,000 International Units of asparaginase Erwinia chrysanthemi, and the following inactive ingredients: glucose monohydrate (5.0 mg), sodium chloride (0.5 mg). "  
ONCOLOGY
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SCHERING PLOUGH
"ELOXATIN® (oxaliplatin injection) is an antineoplastic agent with the molecular formula C8H14N2O4Pt and the chemical name of cis-[(1 R,2 R)-1,2-cyclohexanediamine-N,N'] [oxalato(2)-O,O'] platinum. Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a leaving group.

ELOXATIN (oxaliplatin) Structural Formula Illustration

The molecular weight is 397.3. Oxaliplatin is slightly soluble in water at 6 mg/mL, very slightly soluble in methanol, and practically insoluble in ethanol and acetone.

ELOXATIN is supplied in vials containing 50 mg, 100 mg or 200 mg of oxaliplatin as a sterile, preservative-free, aqueous solution at a concentration of 5 mg/ml. Water for Injection, USP is present as an inactive ingredient."   
ONCOLOGY
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SANOFI PASTEUR     
HEPATITIS VACCINE
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PFIZER   
"ERAXIS for injection is a sterile, lyophilized product for intravenous (IV) infusion that contains anidulafungin. ERAXIS (anidulafungin) is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls.

ERAXIS (anidulafungin) is 1-[(4R,5R)-4,5-dihydroxy-N2-[[4“-(pentyloxy)[1,1':4',1”-terphenyl]-4-yl]carbonyl]-Lornithine]echinocandin B. Anidulafungin is a white to off-white powder that is practically insoluble in water and slightly soluble in ethanol. In addition to the active ingredient, anidulafungin, ERAXIS for Injection contains the following inactive ingredients:

50 mg/vial - fructose (50 mg), mannitol (250 mg), polysorbate 80 (125 mg), tartaric acid (5.6 mg), and sodium hydroxide and/or hydrochloric acid for pH adjustment.

100 mg/vial - fructose (100 mg), mannitol (500 mg), polysorbate 80 (250 mg), tartaric acid (11.2 mg), and sodium hydroxide and/or hydrochloric acid for pH adjustment.

The empirical formula of anidulafungin is C58H73N7O17 and the formula weight is 1140.3."    ANTIFUNGAL
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GENZYME   
"Fabrazyme® (agalsidase beta) is a recombinant human α-galactosidase A enzyme with the same amino acid sequence as the native enzyme. Purified agalsidase beta is a homodimeric glycoprotein with a molecular weight of approximately 100 kD. The mature protein is comprised of two subunits of 398 amino acids (approximately 51 kD), each of which contains three N-linked glycosylation sites. α-galactosidase A catalyzes the hydrolysis of globotriaosylceramide (GL-3) and other α-galactyl-terminated neutral glycosphingolipids, such as galabiosylceramide and blood group B substances to ceramide dihexoside and galactose. The specific activity of Fabrazyme (agalsidase beta) is approximately 70 U/mg (one unit is defined as the amount of activity that results in the hydrolysis of 1 rjmoie of a synthetic substrate, p-nitrophenyl-α-D-galactopyranoside, per minute under the assay conditions).

Fabrazyme (agalsidase beta) is produced by recombinant DNA technology in a Chinese Hamster Ovary mammalian cell expression system.

Fabrazyme (agalsidase beta) is intended for intravenous infusion. It is supplied as a sterile, nonpyrogenic, white to off-white, lyophilized cake or powder for reconstitution with Sterile Water for Injection, uSp. Each 35 mg vial contains 37 mg of agalsidase beta as well as 222 mg mannitol, 20.4 mg sodium phosphate monobasic monohydrate, and 59.2 mg sodium phosphate dibasic heptahydrate. Following reconstitution as directed, 35 mg of agalsidase beta (7 mL) may be extracted from each 35 mg vial.

Each 5 mg vial contains 5.5 mg of agalsidase beta as well as 33.0 mg mannitol, 3.0 mg sodium phosphate monobasic monohydrate, and 8.8 mg sodium phosphate dibasic heptahydrate. Following reconstitution as directed, 5 mg of agalsidase beta (1 mL) may be extracted from each 5 mg vial."   
FABRY'S DISEASE
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PFIZER   
"We are able to supply a wide range of Vaccines and Biological products like Anti Toxins and Sera. We work with Multinational as well as WHO Prequalified Indian manufacturers for their Vaccines. We are able to offer the following products including anti rabies vaccine, oral polio vaccine, hepatitis b vaccine, vaccines and serum, influenza vaccine, meningitis vaccine, chicken pox vaccine etc.
* Oral Polio Vaccine * Hepatitis B Vaccine * Influenza Vaccine * Anti Rabies Vaccine * DPT Vaccine * MMR Vaccine * TD Vaccine * Meningitis Vaccine * Chicken Pox Vaccine * Trivalent Vaccine, Quadrivalent Vaccines/ Pentavalent Vaccines etc."   
ONCOLOGY
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GSK   
"FLUARIX, Influenza Vaccine, for intramuscular injection, is a sterile colorless and slightly opalescent suspension. FLUARIX is a vaccine prepared from influenza viruses propagated in embryonated chicken eggs. Each of the influenza viruses is produced and purified separately. After harvesting the virus-containing fluids, each influenza virus is concentrated and purified by zonal centrifugation using a linear sucrose density gradient solution containing detergent to disrupt the viruses. Following dilution, the vaccine is further purified by diafiltration. Each influenza virus solution is inactivated by the consecutive effects of sodium deoxycholate and formaldehyde leading to the production of a “split virus.” Each split inactivated virus is then suspended in sodium phosphate-buffered isotonic sodium chloride solution. The vaccine is formulated from the 3 split inactivated virus solutions.

FLUARIX has been standardized according to USPHS requirements for the 2014-2015 influenza season and is formulated to contain 45 micrograms (mcg) hemagglutinin (HA) per 0.5-mL dose, in the recommended ratio of 15 mcg HA of each of the following 3 strains: A/Christchurch/16/2010 NIB-74XP (H1N1) (an A/California/7/2009-like virus), A/Texas/50/2012 NYMC X-223A (H3N2), and B/Massachusetts/2/2012 NYMC BX-51B.

FLUARIX is formulated without preservatives. FLUARIX does not contain thimerosal. Each 0.5-mL dose also contains octoxynol-10 (TRITON® X-100) ≤ 0.085 mg, a-tocopheryl hydrogen succinate ≤ 0.1 mg, and polysorbate 80 (Tween 80) ≤ 0.415 mg. Each dose may also contain residual amounts of hydrocortisone ≤ 0.0016 mcg, sulfate ≤ 0.15 mcg, ovalbumin ≤ 0.05 mcg, formaldehyde ≤ 5 mcg, and sodium deoxycholate ≤ 50 mcg from the manufacturing process.

The tip caps and plungers of the prefilled syringes of FLUARIX are not made with natural rubber latex."   
FLU VACCINE
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GSK      
ANTI THROMBOTIC
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ELI LILLY   
"Gemini Description
Gemini-born are quick witted and always on their toes. Gemini is represented by the symbol of Twins. Gemini-born are charming and friendly individuals, who like to indulge in talking, and they talk quite a lot. It is the very curiosity and cleverness that makes them such a hit at the parties and social gatherings. But, the Gemini are not merely good talkers, they also love to listen, to learn and to react. Their life, in total, revolves around their need to communicate. The conversations that Gemini indulge in are not always just idle chats. Most Gemini need an incoming flow of information to feed their intellectual inclinations. In fact, they may probe endlessly for more facts and details, as for them the more information they process, the better it is. Relationships too are very important to the Gemini, and that is why you would always find the Gemini taking time out from their busy schedules to meet people from the different walks of life, and learn from their experiences – these experiences better equip them to nurture their relationship with their friends and family members positively. Handle your relationships even better with the help of the totally personalised Birth Chart based service Relationships Ask 3 Question Detailed OR Saas Bahu Compatibility Reading.

Gemini-born are rational and practical by nature, and at the same time they are also imaginative and creative beings. However, Gemini-born face a major problem and that is about their double thinking nature. Most of the times, it’s not sure which Twin might show up and this certainly makes them seem restless and erratic. At times, they can be quite moody and act on simple impulse. It is this liberal energy, which can also regard them as flyaway and unfocused, behind all that restlessness. While their expansiveness may be misinterpreted as shrewd by some, the Gemini generally have their hearts in the right place. To gain a deeper insight into your future prospects, try the Birth Chart based servic"   
ONCOLOGY
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NOVONORDISK   
"NovoSeven ® is recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting
hemostasis by activating the extrinsic pathway of the coagulation cascade. 1 NovoSeven is a
vitamin K-dependent glycoprotein consisting of  406 amino acid residues (MW 50 K Dalton).
NovoSeven is structurally similar to human plasma-deriv ed Factor VIIa. The gene for human Factor VII is cloned and expressed in baby hamster kidney cells (BHK cells). Recombinant FVII is secreted into the culture media (containing newborn calf serum) in its single-chain form and then proteolytically converted by autocatalysis to the active two-chain form, rFVIIa, during a chromatographic purification process. The purification process has been demonstrated to remove exogenous viruses (MuLV, SV40, Pox virus, Reovirus, BEV, IBRvirus). No human serum or other proteins are used in the production or formulation of NovoSeven. NovoSeven is supplied as a sterile, white lyophilized powder of rFVIIa in single-use vials. Each vial of lyophilized dr
ug contains the following: Conten"   
FACTOR VIII
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SANOFI PASTEUR       
CHICKEN POX VACCINE
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Chaitanya Shah (Director)
Padhya Building, 2nd Floor, 11, Bhaskar Bhau Lane, Gamdevi
Mumbai - 400007
Maharashtra, India
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